Keywords : fibromyalgia


The Role of Interleukin-8 in Patients with Primary Fibromyalgia

Enas J. Kadim; Munaf S. Daoud; Mohammed H. Alosami

Iraqi Postgraduate Medical Journal, 2011, Volume 10, Issue 3, Pages 347-351

ABSTRACT:
BACKGROUND:
Fibromyalgia syndrome (FMS) is a common rheumatologic syndrome with multiple manifestations and associated with many diseases, it characterized by chronic wide spread muscular pain and tenderness. Further, circulatory levels of pro-inflammatory cytokines like IL-8 and others may be altered in FMS patients, possibly associated with their symptoms.The objective of the study is to measure IL-8 concentration and to evaluate its role in the pathogenesis of primary FMS.
OBJECTIVE:
Fifty patients with primary FMS were included in the study (37 females and 13 males) the age range of (17-65) years (Mean ± SD) (40.13 ± 12.0) years, and thirty healthy individuals volunteers (21 females and 9 males), whose age and sex matching with FMS patients, age ranging (18 - 63) years, (Mean ± SD) (36.1 ±10.0) years.
METHODS:
IL-8 concentration was measured in sera of patients and controls by ELISA kit. Anthropometric measurements like body mass index (BMI) and waist circumference (WCr) were taken ,besides other features like sleep disturbance , emotional distress , and fatigue were reported.
RESULTS:
IL-8 concentration was higher in FMS patients than controls(40.24±22.0) pg/ml vs. (19.16±7.8) pg/ml. This elevation was highly significant statistically (p=0.000).Other measurements in patients group like BMI, WCr were(28.39±5.0) Kg/m2 and (100.34±13.21) cm respectively .These values were highly significant when compared to their control group (p=0.002)and (p=0.008) respectively .Clinical features like sleep disturbance, emotional distress ,and fatigue showed highly significant difference between the two groups . No significant differences were reported with respect to age and sex.
CONCLUSION:
The result of the current study suggest that interleukin-8, (IL-8) might have a role in the pathogenesis of FMS.

Lipid Peroxidation and Oxidative Stress in Patients with Fibromyalgia Syndrome

Halla G. AL-Gebouri; Zuhair AL-Mashhadani; Mohammad H. AL-Osami; Kisma M. Turki

Iraqi Postgraduate Medical Journal, 2011, Volume 10, Issue 1, Pages 101-105

ABSTRACT:
BACK GROUND:
Fibromyalgia (FMS) is a common, chronic widespread pain syndrome usually associated with other somatic and psychologic symptoms including fatigue, sleep disturbances, cognitive difficulties Oxidative stress means an alteration in the delicate balance between free radicals and the scavenging capacity of antioxidant enzymes in favor of free radical in the body system.
OBJECTIVE:
To evaluate and compare the antioxidants and lipid peroxidation in patients with fibromyalgia and healthy control.
PATIENTS AND METHOD;
The study has included sixty patients with FMS (40 females and 20 males) and thirty healthy subjects. The subjects were selected from people attending the out patients clinic in Medical City- Baghdad Teaching Hospital- Rheumatology& Rehabilitation Consultation Unit. Laboratory parameters included: uric acid,albumin,caeruloplasmin,total thaiol,malondiaaldehyde(MDA) and peroxinitrate(ONOO¯ ).
RESULTS:
MDA and uric acid levels in serum of patients with fibromyalgia were significantly higher than in the control group. While the levels of ONOO¯ GSH,CP,albumin in serum of patients with fibromyalgia were significantly lower than in healthy control.
CONCLUSION:
oxidative stress may have a role in the pathophysiology of fibromyalgia syndrome.

Prevalence of Fibromyalgia Syndrome in Patients with Haemophilia A

Khudir Z. Mayouf; Faiq Isho Gorial; Najem Abd Jasim; Asaad Abdullah Abbas

Iraqi Postgraduate Medical Journal, 2010, Volume 9, Issue 1, Pages 80-83

ABSTRACT:
BACKGROUND:
Fibromyalgia syndrome is a common rheumatological syndrome with multiple systemic manifestations which could occur alone or associated with many diseases.
OBJECTIVE:
To detect the possible relation between fibromyalgia and haemophilia-A patients.
PATIENTS AND METHODS:
One hundred patients with haemophilia-a were studied and compared with another hundred, healthy individuals matched for age and sex, serving as control group. Full history was taken and complete clinical examination was done for all individuals in both groups.
The american college of rheumatology 1990 criteria for fibromyalgia were applied for both groups. They were questioned about presence of chronic widespread pain, sleep disturbance, headache fatigue and parasthesia . Detection of at least 11 of 18 tender points by digital palpation of specific soft tissue sites were needed for diagnosis of fibromyalgia.
RESULTS:
There was a significant increase in the frequency of fibromyalgia among individuals with haemophilia-a (25%) compared to healthy control group (3%) (p=0.000004, odd ratio=0.093, 95% confidence interval 0.027-0.319).
CONCLUSION:
Fibromyalgia occurs with high frequency in hemophilia A patients

Prevalence of Fibromyalgia in Iraqi People with Joint Hypermobility Syndrome

Khudhir Zghayer Mayouf Al-Bidri

Iraqi Postgraduate Medical Journal, 2008, Volume 7, Issue 1, Pages 18-21

ABSTRACT:
BACKGROUND:
Joint hypermobility occur when large or small joints in the body are able to extend beyond their
normal physiological limits. Fibromyalgia is characterized by chronic diffuse pain. Both conditions
are shared with various soft tissue problems and this draw the attention of a lot of researchers and
clinicians to look for possible relations between them.
OBJECTIVE:
To detect the correlation between firbomyalgia in Iraqi people with joint mobility.
METHODS:
One hundred Iraqi individuals with joint hypermobility syndrome according to the Beighton Score
were studied and compared with another hundred normal mobile individuals matched for age and sex
serving as control group. Full history was taken and complete clinical examination was done for all
individuals in both groups. The American College of Rheumatology 1990 Criteria for fibromyalgia
were applied for all individuals in both groups. They were quationed about presence of chronic
widespread pain, sleep disturbance, mood change and fatigue. Detection of at least 11 of 18 tender
points by digital palpation at specific soft tissue sites was needed for diagnosis of FMS.
RESULTS:
There was statistically significant increase frequency of fibromyalgia among individuals with
hypermobile joints compared to normal mobile people. The frequency was 22% in the individuals
with hypermobile joints versus 11% in the individuals with normal mobile joints, which was reported
mainly in females between the age 30-59 years.
CONCLUSION:
The results showed significant relationship between fibromyalgia and joint mobility.