Keywords : gestational trophoblastic disease

A Prospective Study of Gestational Trophoblastic Disease in Al-Mosul City

Zhraa Abd-Alkader Taboo

Iraqi Postgraduate Medical Journal, 2013, Volume 12, Issue 2, Pages 268-276

Gestational trophoblastic tumors comprise a wide spectrum of neoplastic disorders that arise from
placental trophoblastic epithelium after abnormal fertilization which is characterized by
trophoblastic hyperplasia and overgrowth of placental villi. There are several histologically distinct
types of gestational trophoblastic diseases GTD: hydatiform mole (complete or partial),
persistant/invasive gestational trophoblastic neoplasia (GTN), choriocarcinoma and placenta site
trophoblastic tumors.
Of the present study is to determine the incidence, clinical presentation and some of its relevant
factors among women admitted to Al-Batool Hospital in Mosul- Iraq.
The study was conducted in Al-Batool Hospital, Department of Gynecology and Obstetrics, Iraq,
Mosul city, from April 2009 to January 2011 as prospective study 9500 patients were analyzed
regarding their history, clinical examination, investigations, risk factor.
During the analysis, the peak incidence of age is between 21 – 25 years (31.2%). The most
common clinical presentation bleeding per vaginal (100%). The peak incidence of the disease is
with para two (36%). Complete hydatidiform mole forming (80%). Partial hydatidiform mole
forming (18.4%). Invasive mole forming (1.6%). The mean level of B-hCGin partial mole before
evacuation is between 3000-4000 mIU/ml. the mean level of B-hCG in complete mole before
evacuation is between 7000-10000 mIU/ml.
Frequency of GTD was higher compared to national and international studies. The disease was
common in young ages, low para and grand multiparous women. Hydatidiform mole was the
commonest type of trophoblastic disease in these patients. Most common presenting complaint was
bleeding per vagina followed by pain in lower abdomen. It appears that the ultrasound is
moderately sensitive in the diagnosis of hydatiform mole pregnancy