Iraqi Postgraduate Medical Journal

Abstract

ABSTRACT:
BACKGROUND:
In renal transplantation, hypomagnesemia is a frequent disturbance associated with the use of calcineurin inhibitors (Cyclosporine and Tacrolimus) and sirolimus. They may cause obligatory renal loss and decrease transcriptional expression of the Mg transporter in the distal collecting tubule.
OBJECTIVE:
Evaluation of serum Magnesium in patients during the first four days post renal transplantation and to find any correlation with different variables.
PATIENTS AND METHOD:
A cross sectional descriptive study was performed at Nephrology and Kidney Transplantation Center- Medical City-Baghdad, Iraq from first of January, 2012 to first of December, 2012. Serum Magnesium was followed in forty patients underwent renal transplantation during the first four days post transplantation. Other variables also was studied to find any correlation with serum Magnesium, include (age, sex, duration dialysis of , calcineurin inhibitors (types and dose) , diabetes mellitus, loop diuretics, urine volume . electrolytes (serum Potassium and s. Calcium) and s.creatinine .
RESULT:
The mean serum Magnesium was (2.87 ± 0.5 mg/dl ) pre transplantation, on 1st day it was (2.3±0.49) and 4thday (2.31±0.67). The mean Post transplantation serum Magnesium was significantly lower than pre transplantation, (P<0.01). Serum Magnesium had statistically significant direct correlation with serum Potassium and s.creatinine and statistically significant inverse correlation with s. Calcium and urine volume. It was significantly lower in those using loop diuretics at 1st day post-transplant (P=0.039). Tacrolimus was associated with lower serum Magnesium level than cyclosporine.
CONCLUSION:
Serum Mg post transplantation was significantly lower than pre transplantation level, and sometime may reach to significant hypomagnesemia. This was significantly correlated with S.K , S.Ca, and S Creatinine,