The Iraqi Board for Medical Specializations
  • Register
  • Login

Iraqi Postgraduate Medical Journal

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 16, Issue 2
  3. Authors

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Advisory Board

Editorial Staff

Publication Ethics

Indexing and Abstracting

News

A Comparative Study Between Single Session Versus Six Sessions Mitomycin C instillation in Patients With Low Risk Non-Muscle Invasive Bladder Cancer

    Zaidan khalaf Saad Dakhil F. Daraji

Iraqi Postgraduate Medical Journal, 2017, Volume 16, Issue 2, Pages 158-163

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

ABSTRACT:
BACKGROUND:
Intra vesicle instillation following trans uretheral resection of low grade and low stage bladder cancer proved its efficacy in reducing recurrence and progression of bladder cancer.
OBJECTIVE:
To compare the efficacy of a single session of mitomycine C versus six sessions mitomycine C following TURBT on recurrence and progression rates in patients with low risk non-muscle invasive bladder cancer.
PATIENTS AND METHODS:
A total of 50 patients with low risk non-invasive bladder cancer were included in a prospective randomized controlled trial. Inclusion criteria include all patients who had a 3cm or less, single, papillary tumor. The tumor was completely resected before were randomized patients into 2 arms; Group one; those who receiving one session mitomycin C instillation of 40 mg (usually within 6 hours) into the urinary bladder. And Group B; Receiving six sessions mitomycin C instillation into the urinary bladder, Median follow up was 24 months. The events studied where the recurrence free rate, the recurrence rate/ year, the number of new tumors developing/year, and progression.
RESULTS:
At 24 months follow up, the recurrence free rate in a single session of mitomycin C instillation (group A) was (70.2%) while in six sessions mitomycin C instillation group was (84.7%) (Group B).
Recurrence rate was ; Group A VS Group B : (10% VS 4 %) and recurrence per year rate (5% VS 2%), were decreased in the six sessions mitomycin C instillation (Group B) compared to the single session mitomycin C instillation (Group A). The number of new tumors per year rate (18% VS 11%), were decreased in the six sessions mitomycin C instillation (Group B) compared to the one session mitomycin C instillation, (Group A). A shorter hospital stay, catheterization period, and low level of local symptoms were noted in one session mitomycin C instillation (Group A) compared to six sessions mitomycin C instillation, (Group B).
CONCLUSION:
Single session mitomycin C given immediately after surgery or within 6 hours after resection may be as effective as six session protocol. This regimen may be cost effective and avoid prolonged hospitalization and catheterization with sex sessions regimen.
Keywords:
    KEYWORDS intra vesicle chro therapy mitomycin
  • PDF
  • XML
(2017). A Comparative Study Between Single Session Versus Six Sessions Mitomycin C instillation in Patients With Low Risk Non-Muscle Invasive Bladder Cancer. Iraqi Postgraduate Medical Journal, 16(2), 158-163.
Zaidan khalaf; Saad Dakhil F. Daraji. "A Comparative Study Between Single Session Versus Six Sessions Mitomycin C instillation in Patients With Low Risk Non-Muscle Invasive Bladder Cancer". Iraqi Postgraduate Medical Journal, 16, 2, 2017, 158-163.
(2017). 'A Comparative Study Between Single Session Versus Six Sessions Mitomycin C instillation in Patients With Low Risk Non-Muscle Invasive Bladder Cancer', Iraqi Postgraduate Medical Journal, 16(2), pp. 158-163.
A Comparative Study Between Single Session Versus Six Sessions Mitomycin C instillation in Patients With Low Risk Non-Muscle Invasive Bladder Cancer. Iraqi Postgraduate Medical Journal, 2017; 16(2): 158-163.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 76
  • PDF Download: 38
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap
Powered by eJournalPlus