Iraqi Postgraduate Medical Journal

Abstract

ABSTRACT:
BACKGROUND:
Colorectal cancer (CRC) is one of the most aggressive common tumors in humans. It is known that development and progression of tumors is associated with deviations in the human immune system.Interleukin-6 (IL-6) is a pro-inflammatory and anti-inflammatory cytokine that it is secreted by T cells and macrophages to stimulate immune response, during infection and after trauma. Antioxidants catalase (CAT), Glutathion (GSH), Ceruloplasmin (CP) and Malondialdehyde (MDA) are substances that when present at low concentrations compared to those of an oxidizable substrate significantly delays or inhibits oxidation of that substrate.
OBJECTIVE:
The main objective of this study is to determine the frequency of IL-6, CAT, GSH, CP and MDA in patients with CRC.
PATIENTS & METHODS:
This study included 40 healthy control donors (20 male and 20 female) and 60 patients with CRC (20 smokers male, 20 non smokers male and 20 non smokers female). They were obtained from the people attending the out Patient Clinic/ Baghdad Teaching Hospital in Medical City. Ages ranges were 40-60 years and matched by age and sex to healthy control donors with mean age 53.24 ± 2.32 years
RESULTS:
The mean values of IL-6 and CP in sera of patients (smoker and nonsmoker groups) with CRC were significantly increased as compared to healthy control donors (P<0.01) and the mean values of CAT, GSH and MDA in sera of patients (smoker and nonsmoker groups) with CRC were significantly decreased as compared to healthy control donors (P<0.01) and results analysis shows that the IL-6, CAT, GSH, CP and MDA of female with CRC are less than of a male.
CONCLUSION:
It is clear from this study that there is a relationship between the levels of IL-6, GSH, CAT, CP, and MDA concentrations and CRC patients and may be a good indicator to evaluate this disease.
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