Effect of Magnesium Sulfate on Hemodynamic Response to CO2 Pneumoperitoneum in Patients Undergoing Laparoscopic Cholecystectomy
Iraqi Postgraduate Medical Journal,
2019, Volume 18, Issue 3, Pages 249-254
Pneumoperitoneum with CO2 insufflation is used during laparoscopic cholecystectomy to facilitate
surgical access as it is a minimally invasive procedure, and despite its benefits when compared to the
open cholecystectomy, it is known that pneumoperitoneum has some adverse physiological effects
including an abrupt increase in the arterial blood pressure and an increase in the heart rate due to
increased catecholamines release.
To investigate the effect of magnesium sulfate on attenuating the hemodynamic response to carbon
dioxide pneumoperitoneum in patients undergoing laparoscopic cholecystectomy.
PATIENTS AND METHODS:
This double blind prospective study was conducted in Rizgari Teaching Hospital in Erbil/Iraq on 60
patients whose ages ranges between (20-45) years to assess the effectiveness of magnesium sulfate in
attenuating the hemodynamic response to cholecystectomy, after dividing the patients into two
groups: group I (magnesium group) and group II control group.
The increase in systolic blood pressure, diastolic blood pressure, mean arterial blood pressure and
heart rate readings were less in group I (Magnesium group) when compared to group II (control
group) with a statistically significant difference (p < 0.05).
It can be concluded that magnesium sulfate attenuates the hemodynamic response to
pneumoperitoneum in laparoscopic cholecystectomy.
KEYWORDS: Magnesium sulfate, Laparoscopic cholecystectomy,
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