Applying P40 and TTF-1 in the Subtyping of Poorly Differentiated Non-Small Cell Lung Carcinoma in Bronchoscopic Biopsy
Iraqi Postgraduate Medical Journal,
2020, Volume 19, Issue 3, Pages 239-245
Lung cancer is the leading cause of cancer-related deaths worldwide, regardless of gender. It is
categorized into two main groups: small cell lung carcinoma (SCLC, 15% of all lung cancers) and
non-SCLC (NSCLC, 85% of all lung cancer). Increasing knowledge of the molecular pathology of
lung cancers has led to their classification into specific subtypes according to appropriate treatments
and molecular-targeted therapies.
Evaluation of the expression of P40 and TTF-1 in randomly selected samples from Iraqi patients
who have NSCLC and correlate their expression with the clinicopathological variables.
PATIENTS AND METHODS:
This is a retrospective study of 40 patients who were diagnosed to have NSCLC. Formalin fixed,
paraffin embedded tissue blocks.P40 and TTF-1 immunoreactivity and pattern of staining were
evaluated in immunohistochemical stained slides and correlated the results with clinicopathological
55% of the tumors were squamous cell carcinoma while 45% were adenocarcinoma. The sensitivity
and specificity of P40 for the SQC diagnosis were 100% while the sensitivity of TTF-1 for ADC
diagnosis was 88.9% and specificity was 100%.
P40 and TTF-1 can be used as a reliable minimalistic panel for accurate subtyping of NSCLC.
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