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Preterm Premature Rupture of Membranes and the Value of Serum Ferritin during Pregnancy

Iraqi Postgraduate Medical Journal, 2020, Volume 19, Issue 4, Pages 350-355
10.52573/ipmj.2020.167330

Abstract

BACKGROUND:
Preterm premature rupture of membranes occurring from 24-37 weeks gestation. Ferritin is an acute phase reactant as it increases during inflammation that inflammation can predispose to preterm premature rupture of membranes during pregnancy.
OBJECTIVE:
To investigate the value of serum ferritin as a marker for preterm premature rupture of membrane.
PATIENTS AND METHODS:
The study includes 150 pregnant women attending the department of Obstetrics and Gynecology with a gestational age ranging from 28+0 – 36+6 weeks. 50 of them presented with Preterm premature rupture of membrane (group A), 50 women were presented with spontaneous preterm labor (group B), and the other 50 were without any complaint (group C). Venous blood samples of five ml were collected on admission for measurement of serum ferritin level by enzyme-linked immunosorbent assay.
RESULTS:
No statistically significant differences between study groups regarding age, parity, gestational age and hemoglobin level (P ≥ 0.05). The mean of serum ferritin was significantly higher among pregnant women presented with Preterm premature rupture of the membranes than those presented with spontaneous preterm labor and healthy women (45.07 versus 26.22 and 22.83 ng/ml respectively) (P= 0.001). By receiver operating characteristic curve analysis, the cut point of serum ferritin value was 38.6 ng/ml.
CONCLUSION:
Measurement of serum ferritin level is a simple rapid and accurate test. It can be applied as a marker for preterm premature rupture of membrane.
 
Keywords:

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