Value of Dynamic Contrast Enhanced Magnetic Resonant Imaging in Detection of Local Recurrence Breast Cancer
Breast cancer has become a major threat to female health in Iraq, with a cancer-related mortality rate of (23%). Despite advances in early diagnosis, treatment, and biomarker identification of breast cancer, it carries a high risk of recurrence, about 20-30% and substantially worse overall survival.
To evaluate the role of dynamic contrast enhanced magnetic resonance imaging in differentiation between benign postoperative changes and recurrent malignant tumors in postoperative patient with breast cancer.
PATIENTS AND METHODS:
Cross-sectional prospective study was performed at MRI unit of Al-Imamein Al-Kadhimein Medical city in Baghdad/ Iraq within the period from January 2019 to January 2020. The study included 29 female patients with 42 detected lesions suspected as local recurrent.All women were recruited for dynamic contrast enhanced (DCE-MRI).
The mean age of 29 patients were 50.58±10.01 years (range 21-66 years). of the 42 detected lesions 22 proved histopathologically as local recurrence (17 were invasive ductal carcinoma, 2 were ductal carcinoma insitu and 3 were invasive lobular carcinoma), the remaining 20 were benign postoperative lesions (8 were fibrosis, 5 were granulation tissue, 5 were fat necrosis, 2 were seroma and 1 was diffuse skin thickening and edema). DCE-MRI study show to have a sensitivity of 95.5%, a specificity of 90%, Positive Predictive Value of 91.3% Negative Predictive Value of 94.7% and an accuracy of 92.86% in differentiation between benign postoperative changes and recurrent malignant tumors.
DCE-MRI is a valuable tool in evaluation of postoperative breast as it has high sensitivity and specificity in differentiation between benign postoperative changes and recurrent malignant tumor.
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