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The Relationship of Urocortin 2 with Insulin Resistance, Clinical, and Biochemical Hyperandrogenism in Women with Polycystic Ovary Syndrome

Iraqi Postgraduate Medical Journal, 2022, Volume 21, Issue 2, Pages 243-249
10.52573/ipmj.2021.174636

Abstract

BACKGROUND: 
Polycystic ovary syndrome is the most common endocrine and metabolic disorder in women. Urocotin-2 is thought to be involved in the pathophysiology of Polycystic ovary syndrome by paracrine and autocrine pathways.
OBJECTIVE:  
To assess the Urocortin-2 level in women with Polycystic ovary syndrome and to assess the relation of urocotin-2 with insulin resistance, clinical and biochemical hyperanderogenism.
PATIENTS AND METHOD: 
a case control study that involved; forty-five polycystic ovary patients according to Rotterdam criteria as a case group, and forty-five healthy women as a control group. Ferriman-Gallwey score was used to evaluate hirsutism, in addition to measurement of Body mass index and Waist/Hip ratio, levels of: Follicle stimulating hormone, luteinizing hormone, Prolactin, testosterone, insulin, fasting blood sugar, homeostatic model assessment of insulin resistance and urocotine-2 also assessed.      
RESULT:
urocotin-2 was significantly higher in Polycystic ovary syndrome compared to control women using Receiver Operating Characteristic Curve  analysis.
CONCLUSION:  
Urocortin-2 may have a role in the pathogenesis of Polycystic ovary syndrome for its correlation with testosterone, homeostatic model assessment of insulin resistance, serum insulin, and Body Mass Index, since there was higher levels than that of normal women.
Keywords:

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