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Transdermal Scopolamine Alternative to Ondansetron for Prevention of Early 6 Hours Postoperative Laparoscopic Cholecystectomy Emetic Symptoms

Iraqi Postgraduate Medical Journal, 2022, Volume 21, Issue 3, Pages 306-310
10.52573/ipmj.2021.175793

Abstract

BACKGROUND:
Nausea and vomiting are the commonest complication Post-operatively which are usually                         self-limiting; however, it can cause serious consequences. There are many drugs to manage                       Post-operative nausea and vomiting.
OBJECTIVE:
Compare the efficacy of transdermal scopolamine versus ondansetron for the prevention of                         post-operative laparoscopic cholecystectomy emetic symptoms.
PATIENTS AND METHODS:
One hundred patients who were candidate for undergoing laparoscopic cholecystectomy are divided in to two groups each of them have 50 patients, first group received an active TDS patch  (containing scopolamine 1.5 mg) 60 min before entering the operating room. The second group was administered ondansetron, 4 mg that was administered I.V near the end of the procedure, and all patients received                a standardized general anesthetic technique.
RESULTS:
There were no significant differences in any of the emetic outcomes orneed for rescue antiemetics between TDS and ondansetron groups inthe first 6 h after surgery.
CONCLUSION:
Premedication with TDS (1.5) mg was as effective as ondansetron (4 mg) in preventing nausea and vomiting in the early postoperative periods. Also less cost with TDS patch.
 
Keywords:

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