Iraqi Postgraduate Medical Journal

Abstract

ABSTRACT:
BACKGROUND:
Adiponectin is thought to be exclusively synthesized by adipocytes; however, a recent suggestion
stated that adiponectin is also synthesized and secreted by human cardiomyocytes. Adipose tissue
is increasingly recognized as a key regulator of energy balance, playing an active role in lipid
storage and buffering, and synthesizing and secreting a wide range of endocrine products that may
be directly involved in the pathogenesis of the complications associated with obesity. So obesity
consider the major independent risk factor for atherosclerotic cardiovascular disease Acute
Myocardial Infarction (AMI), is the interruption of blood supply to part of the heart, causing some
heart cells to die. Insulin is a very important hormone as it regulates the level of glucose, in the
blood. Troponin is a complex of three regulatory proteins that is integral to muscle contraction in
skeletal and cardiac muscle.
OBJECTIVE:
To monitor adiponectin level and its effect on lipid profile and Troponin levels in Acute
Myocardial infarction patients.
SUBJECTS AND METHODS:
The study included 50 patients with Acute Myocardial infarction and forty healthy subject as
control group. This study designed to measure adiponectin, lipid profile and troponin levels.
RESULTS:
Levels of adiponectin, cholesterol, LDL-C and Troponin were significantly elevated with
(p<0.001), while HDL-C was significantly lower with (p<0.001), There was negative correlation
between adiponectin with , cholesterol LDL-C, triglyceride and VLDL, and there was positive
correlation between adiponectin with HDL in acute myocardial infarction.
CONCLUSION:
The significant increase in adiponectin in AMI may be related to inflammation. From the relation
of adiponectin with lipid profile, adiponectin can increase level of HDL and decrease level of
triglyceride so this suggested that adiponection have anti-atherosclerosis properties