Immunological Evidence In Idiopathic Dilated Cardiomyopathy
Iraqi Postgraduate Medical Journal,
2012, Volume 11, Issue 1, Pages 103-106
Immunological factors in the pathogenesis of idiopathic dilated cardiomyopathy (IDC) were
suggested previously on the basis of the demonstration of mononuclear cell infiltrates and
autoantibodies against the myocardium.
Was to determine the changes in the percentage of T cell subsets in peripheral blood in order to
investigate the role of cellular immunoregulation in patients with idiopathic dilated
PATIENT AND METHOD:
The surface markers of peripheral T and B lymphocytes were detected and percentages of helper
(CD4+) and suppressor (CD8+) T lymphocytes subsets in the peripheral blood and their ratio.
(CD4+/CD8+) were determined in 62 patients with IDC and in 50 healthy controls.
There were no significant differences between IDC and control groups with respect to CD4+ T cell
subsets ( p=0.4). CD8+ T cell percentage was significantly decreased in patients with IDC than in
controls (p=0.005). CD4+/CD8+ ratio was markedly higher in patients with IDC than controls
Decreased CD8+ T cell subset is the cause of increased CD4+/CD8+ ratio, which may imply
decreased self-tolerance and an immunoregulatory defect in the pathogenesis of IDC.
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