The Iraqi Board for Medical Specializations
  • Register
  • Login

Iraqi Postgraduate Medical Journal

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 6, Issue 3
  3. Author

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Advisory Board

Editorial Staff

Publication Ethics

Indexing and Abstracting

News

The Efficacy of Dextran 70 on Reticuloendothelial System in Systemically Infected Mice with Klebsiella Pneumoniae

    Jamela Gh. Auda

Iraqi Postgraduate Medical Journal, 2007, Volume 6, Issue 3, Pages 256-262

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

ABSTRACT: BACKGROUND: The reticuloendothelial system (RES) play an important role in immunity against bacterial infection and Klebsiella pneumoniae one of the most common causes of hospital-acquired infections. Dextran70 (D70), a polysaccharide, may alter functions of this system through changing many biological activities in the tissues. OBJECTIVE: This study focuses on the prophylactic effects of D70 on RES in systemically challenged mice with K. pneumoniae which has been isolated from urine sample of patient with urinary tract infection. METHODS: Four groups of adult white mice were intravenously injected with K.pneumoniae. Three groups of them was preinjected intraperitonealy for three successive days with 0.5 , 1, and 2 mg D70/100 g body weight, and the fourth group was challenged only as a control group. The ratio of liver and spleen weights to body weight was calculated and histological sections for heart, lung, and kidney were examined after 24 and 48 hours from challenge in all groups. RESULT: The results revealed that an increasing in the ratio of liver weights to body weight in control group, while there is slight increase in the three groups treated with D70. The ratio of spleen weights to body weight was more increasing after 24 hours in both 0.5 and 2 mg D70/100 g body weight of treated groups. The histological study demonstrated suppurative lesions and abscesses in the heart, lung, and kidney due to K. pneumoniae infection in the control group, while pretreated mice with D70 have clearly demonstrated less pathological changes and more integrity of the tissues comparative to control group
Keywords:
    Dextran Klebsiella pneumoniae Immunomodulator
  • PDF
  • XML
(2007). The Efficacy of Dextran 70 on Reticuloendothelial System in Systemically Infected Mice with Klebsiella Pneumoniae. Iraqi Postgraduate Medical Journal, 6(3), 256-262.
Jamela Gh. Auda. "The Efficacy of Dextran 70 on Reticuloendothelial System in Systemically Infected Mice with Klebsiella Pneumoniae". Iraqi Postgraduate Medical Journal, 6, 3, 2007, 256-262.
(2007). 'The Efficacy of Dextran 70 on Reticuloendothelial System in Systemically Infected Mice with Klebsiella Pneumoniae', Iraqi Postgraduate Medical Journal, 6(3), pp. 256-262.
The Efficacy of Dextran 70 on Reticuloendothelial System in Systemically Infected Mice with Klebsiella Pneumoniae. Iraqi Postgraduate Medical Journal, 2007; 6(3): 256-262.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 88
  • PDF Download: 76
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap
Powered by eJournalPlus