Iraqi Postgraduate Medical Journal

Abstract

ABSTRACT:
BACKGROUND:
Infectious mononucleosis is caused by the ubiquitous Epstein-Barr virus .It is a common condition usually adolescents and young adults. Most cases are mild to moderate in severity with full recovery taking place over several weeks. More sever cases and unusual complications occasionally occur.
AIMS OF THE STUDY:
Determining the role of theTh1and Th2 in infectious mononucleosis –like syndrome by measuring IL-10.
METHODS:
Enzyme immunoassay for Quantitative Determination of human Interleukin-10 in serum.
RESULTS:
of cytokines showed a significant increase in IL-10 in patients with EBV infection (122.3±34.97)pg/ml. In non EBV infection the level of IL-10 was also increase (74.24±18.84)pg/ml when compared with the healthy control (2.2±0.86) pg/ml. There was high significant difference between them (p<0.001).
CONCLUSION:
High levels of IL-10 may be referred to a TH1/TH2 response in infectious mononucleosis like- syndrome in comparison with healthy control group.