The Role of Anticardiolipin and Anti-B2 Glycoprotein Antibodies in Clinical Complication of Lupus Nephritis
Iraqi Postgraduate Medical Journal,
2008, Volume 7, Issue 1, Pages 22-25
Although there was confliction regarding the association of raised anticardiolipin antibodies (ACL)
level with renal disease in systemic lupus erythematosus (SLE), the role of B2glycoprotein as a
cofactor for ACL binding is established.The presence of ACL &anti-B2GPІ may be directly
involved in pathogenesis of antiphospholipid antibodies associated symptoms like recurrent fetal
loss, thrombocytopenia and thrombosis.
AIM OF STUDY:
To study the possible association between some auto antibodies with the most common clinical
complication of disease.
PATIENTS AND METHODS:
The study was conducted on 25 patients with lupus nephritis, attended the renal clinic in
specialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritis and 25
healthy controls. Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP.
Although there was no significant difference in mean concentrations of ACL and anti- B2GP
between lupus nephritis and without nephritis (P>0.05), lupus nephritis patients were more likely
positive for ACL. Positivity of 100% For ACL & anti- B2GPwere detected in thrombotic
complication, in fetal loss complication patients more likely to be positive for ACL (75%), anti-
B2GP (50%), in thrombocytopenia positivity of ACL &anti-B2GP (75%).
There was no association between anti-B2GP and renal disease and presence of both ACL &anti-
B2GP carry higher risk for thrombosis and recurrent fetal loss.
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