Iraqi Postgraduate Medical Journal

Abstract

SUMMARY:
Diabetes mellitus is a heterogeneous group of disorders characterized by abnormalities in carbohydrate ,protein , and lipid metabolism ,which is due either to insulin production or action . Diabetes is a leading cause of blindness , kidney disorders , disease of small blood vessels ……………and various other malfunctions. So the
AIM:
of this study is to investigate the effect of cinnamon oil as a natural source of a wide scale of antioxidants on prevention and treatment of oxidative stress in alloxan – induced diabetic animals , through biochemical and histochemical studies.
MATERIALS AND METHODS :
Thirty – five hamsters were employed in this study . They were divided into 4 groups . 1st group : 5 = animal control , 2nd group :10 = treated with alloxan , 3 rd group , 10 = treated with cinnamon oil and 4 th group , 10 = treated with alloxan and cinnamon .
RESULTS :
Renal tissues ( Bowman's capsule, proximal and distal convoluted tubules ) of alloxan – treated group revealed obvious increase in acid ( ACP ) and alkaline ( ALP ) phosphatase activity . While the 4 th group showed clear decrease in the activity of these enzymes as compared with group I & group III . CONCLUSION :
Cinnamon-oil can be recommended as an support for the prevention of alloxan – induced diabetic complications