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The Correlation Between Insulin ,IL-6 and CRP in Acute Myocardial Infarction

    lmmmA Esmaeel Ibrahim Hadef Dhafer EL-Yassin Hamid Kareem Sachit AL-Janabi

Iraqi Postgraduate Medical Journal, 2012, Volume 11, Issue 4, Pages 536-541

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Abstract

ABSTRACT:
BACKGROUND:
Insulin is a hormone produced by the beta cells of the pancreas. Insulin is necessary for the uptake of glucose into all cells in the body other than the Brain. C reactive protein (CRP) is a main inflammatory factor that is produced by the liver during acute infection or inflammation and its concentration in plasma can increase as much as 1000-fold during injury and infection. Interleukin-6 (IL-6), a major regulatory proinflammatory cytokine, is produced by a variety of cells, including leukocytes, adipocytes, and endothelial cells, and acts on the liver to stimulate the production of a number of acute-phase proteins.
OBJECTIVE:
The present study was designed to examine the relationship between fasting plasma IL-6 and CRP concentrations and insulin action in acute myocardial infarction patients.
SUBJECTS AND METHODS:
The study included 50 patients with acute Myocardial infarction (AMI) and forty healthy subjects as control group. Levels of insulin, CRP and IL-6 were measured.
RESULTS:
The levels of insulin, IL-6 and CRP were significantly elevated in AMI patients with (p<0.001). There was positive correlation between insulin with CRP and IL-6 in acute myocardial infarction patients.
CONCLUSION:
The significant increase in insulin in AMI may be related to inflammation. Insulin positively correlated with inflammatory markers (CRP and IL-6)
Keywords:
    Insulin CRP acute myocardial infarctio
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(2012). The Correlation Between Insulin ,IL-6 and CRP in Acute Myocardial Infarction. Iraqi Postgraduate Medical Journal, 11(4), 536-541.
lmmmA Esmaeel Ibrahim; Hadef Dhafer EL-Yassin; Hamid Kareem Sachit AL-Janabi. "The Correlation Between Insulin ,IL-6 and CRP in Acute Myocardial Infarction". Iraqi Postgraduate Medical Journal, 11, 4, 2012, 536-541.
(2012). 'The Correlation Between Insulin ,IL-6 and CRP in Acute Myocardial Infarction', Iraqi Postgraduate Medical Journal, 11(4), pp. 536-541.
The Correlation Between Insulin ,IL-6 and CRP in Acute Myocardial Infarction. Iraqi Postgraduate Medical Journal, 2012; 11(4): 536-541.
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