Iraqi Postgraduate Medical Journal

Abstract

ABSTRACT:
BACKGROUND:
The likelihood of developing end-stage renal disease in an individual is determined by interactions between genetic and environmental factors. Human leukocyte antigen is the most polymorphic genetic system in man. Genes of this region influence susceptibility to certain diseases.
OBJECTIVE:
The purpose of the present study is to investigate the association of HLA class I (HLA-A and HLA-B) with the end-stage renal disease in Iraqi patients (Arab and Kurd).
SUBJECTS AND METHODS:
HLA-typing was assessed in 200 patients with end-stage renal disease and 110 healthy controls by microlymphocytotxicity assay.
RESULTS:
A survey of the distribution of HLA-A and HLA-B antigens frequencies yielded a significant variation between patients and healthy control group. Arab patients have significant increase in frequency of HLA-A2 as compared with healthy control (P=0.005). Whereas Kurdish patients revealed significant increase in frequency of HLA-B35 when compared with healthy control (P=0.033).
CONCLUSION:
The current study suggests that high frequency of HLA-A2 in Arab patients and HLA-B35 in Kurdish patients might be associated with susceptibility to risk of end-stage renal disease