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Hemolytic Uremic Syndrome Epidemiological and Clinical Facts

    Najla Ibrahiem Ayoub Ahmed Hameed Mohammed Jinan Soaod Orabi Asaad Abdullah Abbas

Iraqi Postgraduate Medical Journal, 2013, Volume 12, Issue 1, Pages 11-17

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Abstract

ABSTRACT: BACKGROUND: Hemolytic uremic syndrome is the most common cause of acute renal failure in children and has high mortality rate. OBJECTIVE: To study the epidemiology, clinical course, management, complications and the important risk factors that affect the outcome of the patients with hemolytic uremic syndrome. PATIENTS AND METHOD: In this retrospective study we collect fifty two patients who were admitted to the Child´s Central Teaching Hospital from the period 1st of Jan. 2005 till 30th May 2008. The data collected from the case records includes: name, sex, age, season, presence of diarrhea, jaundice, family history of HUS, complications, associated clinical features such as: pallor, edema, rash, hypertension, hepatosplenomegaly, and coarse of the disease. Also Laboratory. Findings as Haemlglobin (Hb), Packet Cell Volume (PCV)%, White Blood Cell (WBC), Red Blood Cell (RBC) morphology, platelets counts, blood urea and serum creatinine; and managements were included in the study. RESULTS: Of total 52 , there were 21 (40.4%) cases below 2 years, the males account 33 (63.46%) from the total. There were seasonal and annual increments. Eighty four percent had diarrheal prodrome, and 1.91% had familial history of HUS. All patients had pallor and acute renal failure. The mean of the hemoglobin was 8.6 gm/dl, WBC count mean was 18 × 109/L, platelets mean was 35 × 109/L, blood urea mean was 180 mg/dl, and the mean of serum creatinine was 3.8 mg/dl. The GIT complications was the commonest 23 (44.23%) followed by CNS complication 16 (30.7%), hypertension was present in 25%. During acute phase of disease 12 (23.07%) patients died. CONCLUSION: HUS affect mainly age between 3 months and 4 years. There was seasonal variation with peak at wormer months.There were statistically significance correlation between high risk patients and age group below 2 years, CNS complication, and non diarrheal prodrome.
Keywords:
    hemolytic uremic syndrome epidemiological
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(2013). Hemolytic Uremic Syndrome Epidemiological and Clinical Facts. Iraqi Postgraduate Medical Journal, 12(1), 11-17.
Najla Ibrahiem Ayoub; Ahmed Hameed Mohammed; Jinan Soaod Orabi; Asaad Abdullah Abbas. "Hemolytic Uremic Syndrome Epidemiological and Clinical Facts". Iraqi Postgraduate Medical Journal, 12, 1, 2013, 11-17.
(2013). 'Hemolytic Uremic Syndrome Epidemiological and Clinical Facts', Iraqi Postgraduate Medical Journal, 12(1), pp. 11-17.
Hemolytic Uremic Syndrome Epidemiological and Clinical Facts. Iraqi Postgraduate Medical Journal, 2013; 12(1): 11-17.
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