The Iraqi Board for Medical Specializations
  • Register
  • Login

Iraqi Postgraduate Medical Journal

Notice

As part of Open Journals’ initiatives, we create website for scholarly open access journals. If you are responsible for this journal and would like to know more about how to use the editorial system, please visit our website at https://ejournalplus.com or
send us an email to info@ejournalplus.com

We will contact you soon

  1. Home
  2. Volume 12, Issue 3
  3. Authors

Current Issue

By Issue

By Subject

Keyword Index

Author Index

Indexing Databases XML

About Journal

Aims and Scope

Editorial Board

Advisory Board

Editorial Staff

Publication Ethics

Indexing and Abstracting

News

Evaluation of Immunohistochemical Staining for Hepatocyte Growth Factor and c-Met in Endometrial Adenocarcinoma

    Lubab Fadhil Talal Mohamed Sabaa Challob

Iraqi Postgraduate Medical Journal, 2013, Volume 12, Issue 3, Pages 335-342

  • Show Article
  • Download
  • Cite
  • Statistics
  • Share

Abstract

ABSTRACT:
BACKGROUND:
Endometrial carcinoma is a primary malignant epithelial tumor, usually with glandular differentiation,
arising in the endometrium with the potential to invade and metastasize. Hepatocyte growth factor
(HGF) and its receptor c- Met have been implicated in uterine development, pregnancy, and
endometrial disorders, such as endometriosis and carcinoma.
OBJECTIVE:
The goal of this study was to evaluate immunohistochemical (IHC) staining patterns of HGF and cMet
in
endometrial
adenocarcinoma
and
to
correlate
staining
with
the
biological
behavior
and
outcome

of
endometrial
adenocarcinoma.

PATIENTS
AND
METHOD:

A

retrospective study included 45 cases ,who underwent total abdominal hysterectomy and bilateral
salpingo-oopherectomy, between 2005-2010 samples ,were taken from Teaching Laboratories at
Baghdad Teaching Hospital/Medical City.
Thirty cases were diagnosed as adenocarcinoma of the endometrium, an additional 15 patients
diagnosed as to have uterine leiomyoma(fibroid) and who had normal endometrium were taken as a
control group. The patient's age ,tumor grading ,depth of myometrial invasion, presence of pelvic and
paraaortic LN metstases, vascular invasion ,and the stage of the disease were noted .
The specimens were already fixed in10% formalin , and paraffin embedded. Three sections (4 micron in
thickness ) were cut from each paraffin block. One section stained with Haematoxylin and Eosin
(H&E) stain , and the other two stained with HGF and c-Met immunostaining antibodies using
positively charged slides .
RESULTS:
The mean age of the patients with endometrial adenocarcinoma was 58.5years.
There was no statistically significant difference between HGF/c-Met expression and age, tumor grade,
stage , myometrial invasion and vascular invasion. There was a statistical significant correlation
between HGF and c-Met scores with cases showing no pelvic lymph nodes metastases.
There is a linear increase in HGF and c-Met expression in both the diseased and control group.A
statistical significant correlation was found in HGF and c-Met scores between the diseased group and
the control group.
CONCLUSION:
HGF and c-Met staining was significantly different between control group and diseased group.
HGF and c-Met Showed Linear increase Expression in both diseased and control group .
The c-Met is the high-affinity receptor for hepatocyte growth factor
Keywords:
    HGF met endometrial adenocarcinoma
  • PDF
  • XML
(2013). Evaluation of Immunohistochemical Staining for Hepatocyte Growth Factor and c-Met in Endometrial Adenocarcinoma. Iraqi Postgraduate Medical Journal, 12(3), 335-342.
Lubab Fadhil Talal; Mohamed Sabaa Challob. "Evaluation of Immunohistochemical Staining for Hepatocyte Growth Factor and c-Met in Endometrial Adenocarcinoma". Iraqi Postgraduate Medical Journal, 12, 3, 2013, 335-342.
(2013). 'Evaluation of Immunohistochemical Staining for Hepatocyte Growth Factor and c-Met in Endometrial Adenocarcinoma', Iraqi Postgraduate Medical Journal, 12(3), pp. 335-342.
Evaluation of Immunohistochemical Staining for Hepatocyte Growth Factor and c-Met in Endometrial Adenocarcinoma. Iraqi Postgraduate Medical Journal, 2013; 12(3): 335-342.
  • RIS
  • EndNote
  • BibTeX
  • APA
  • MLA
  • Harvard
  • Vancouver
  • Article View: 186
  • PDF Download: 142
  • LinkedIn
  • Twitter
  • Facebook
  • Google
  • Telegram
  • Home
  • Glossary
  • News
  • Aims and Scope
  • Privacy Policy
  • Sitemap
Powered by eJournalPlus