Iraqi Postgraduate Medical Journal

Abstract

BACKGROUND :
Magnesium (( Mg
(1)

)) is a mineral that is involved in over 300 reactions in the body. Magnesium is a
Potent vasodilation ,and plays an important role in muscle contraction. It has been early
documented that Mg deficiency can precipitate ventricular arrhythmias and treatment with Mg
has
some anti arrythmic effect. Moreover there is an ample evidence that a significant percentage of
patients with IHD suffer from Mg
. The risk of IHD increases
with age, smoking, hypercholesterolaemia,
diabetes mellitus, hypertension
(1)
. Ischemic heart
disease presented as stable angina , unstable
angina , myocardial infarction , ischemic heart
failure and ischemic cardiomyopathy
. The
diagnosis of ischemic heart disease depend on
clinical history and investigation including:

*Ministry of Health AL-Bitar Hospital,Baghdad
.Iraq.
**Biochemistry Dept. Collage of Medicine
University of Baghdad.
*** Dept. Baghdad Medicine City.



deficiency.
OBJECTIVE :
The objective of the present study is to measure Mg
(2)

levels in serum and RBCs of patients with
some forms of IHD.
PATIENTS AND METHODS:
The study was conducted in Baghdad hospital and Ibn – Al-Bitar Hospital.The 180 patients with
IHD were divided into Two groups. Group I, 80 patients with Ischemic Heart Failure (IHF)
(EF˂30) aged 65.75±5.97 year (50 males and 30 females), group II, 100 patients with
Muocardial Infarction
(MI)(EF˂50) aged 50.34±6.36 year (58 males and 42 females). Serum Mg and RBCs Mg
were
measured in all patient groups by Atomic Absorption Spectrophotometer.
RESULTS:
The(mean ±SD) value of serum and RBCs Mg in patients with both groups Ischemic Heart Disease
(IHD) was significantly lower when compared with that of controls (p<0.05).The serum Mg levels
(0.81±SD mmol/L) are significantly lower in the IHF group and in MI group (0.96±0.18 mmol/L)
when compared with that of controls (1.00±0.17 mmol/L) (p˂ 0.001).
CONCLUSION:
The data obtained in present study revealed the decrease of Mg level in serum and RBCs
in both
patients groups, which affect the contractility of heart muscle and cardiac performance