Iraqi Postgraduate Medical Journal

Abstract

ABSTRACT:
BACKGROUND:
Children with cancer who are on intensive chemotherapy require multiple blood and its products transfusion which increases the risk of blood transmissible infection
OBJECTIVE:
To know the prevalence of HBV and HCV infection in pediatric malignancy after starting anti cancer therapy and To identify the risk factor, that increased the possibility of infection
Design a Prospective interventional study
Participants The present study was conducted on 85 children with malignancies who were attending the department of pediatric oncology in Mosul,(Ibn-Alather hospital) the age of the patients were between 1-15 years with male: female ratio of 1.5: 1
Main outcome measure. All our patients were tested for HBsAg and HCV antibodies at diagnosis of malignancy and before starting chemotherapy then after six and twelve months
RESULTS:
Two patients (2.3%) had HBV infection, and no patient had HCV infection initially, while after 6 month of receiving chemotherapy we have 8/70 (11.4) had HBV and also no patient with HCV, and after 12 months of receiving chemotherapy the percentage of patients with HBV and HCV were increase to 13/63 (20.6%) and 2/63 (3.2%) respectively .
CONCLUSION:
Its important to ensure on accurate screening of blood and its products before transfusion to these patients, and also ensure on the receiving HB vaccine before starting chemotherapy. Before this study, the prevalence of HBV and HCV infection in pediatric malignancy in Mosul city were unknown, the present study was designed to fill this gap.
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